Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering

@article{Regg1992RoleOI,
  title={Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering},
  author={Curzio R{\"u}egg and Antonio A. Postigo and Ewa Sikorski and Eugene C. Butcher and Robert Pytela and David J. Erle},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={117},
  pages={179 - 189}
}
Integrins are heterodimeric cell surface proteins that mediate both cell-cell and cell-extracellular matrix interactions. We and others recently identified cDNAs encoding a novel integrin beta subunit, beta 7, in lymphocytes. We have now detected beta 7 mRNA in mouse TK-1 T lymphoma cells, which are known to express the putative Peyer's patch homing receptor alpha 4 beta P. We used an anti-peptide antiserum and a novel mAb against the beta 7 subunit to show that TK-1 cells express beta 7 as the… CONTINUE READING

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