Role of insulin receptor and the balance in the insulin receptor isoforms A and B in the regulation of apoptosis in SV 40-immortalized neonatal hepatocytes

Abstract

We have investigated the unique role of the insulin receptor (IR) and the balance of its isoforms A and B in the regulation of apoptosis in SV40-immortalized neonatal hepatocytes. Immortalized hepatocytes lacking (HIR KO) or expressing the entire IR (HIR LoxP), and cells expressing either IRA (HIR RecA) or IRB (HIR RecB) have been generated. IR deficiency… (More)

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