Role of insulin-like growth factor 1 receptor and c-Src in endothelin-1- and angiotensin II-induced PKB phosphorylation, and hypertrophic and proliferative responses in vascular smooth muscle cells.

@article{Bouallegue2009RoleOI,
  title={Role of insulin-like growth factor 1 receptor and c-Src in endothelin-1- and angiotensin II-induced PKB phosphorylation, and hypertrophic and proliferative responses in vascular smooth muscle cells.},
  author={Ali Bouallegue and George Vardatsikos and Ashok K. Srivastava},
  journal={Canadian journal of physiology and pharmacology},
  year={2009},
  volume={87 12},
  pages={1009-18}
}
Endothelin-1 (ET-1) and angiotensin II (Ang II) are vasoactive peptides believed to contribute to the pathogenesis of vascular abnormalities such as hypertension, atherosclerosis, hypertrophy, and restenosis. The concept of transactivation of growth factor receptors, such as epidermal growth factor receptor (EGFR), in triggering vasoactive peptide-induced signaling events has gained much recognition during the past several years. We have demonstrated that insulin-like growth factor type 1… CONTINUE READING

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Cloning and expression of a cDNA encoding an endothelin receptor

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