Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion

@article{Zhang2004RoleOI,
  title={Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion},
  author={Hai Feng Zhang and Qian Fan and X. X. Qian and Bernard L. Lopez and Theodore A. Christopher and Xin L. Ma and Feng Gao},
  journal={Apoptosis},
  year={2004},
  volume={9},
  pages={777-783}
}
Objective: To study the effects of glucose-insulin-potassium (GIK) cocktail on cardiac myocyte apoptosis and cardiac functional recovery following myocardial ischemia/reperfusion (MI/R), and to further determine the role of insulin in the GIK-induced cardioprotective effect in vivo. Methods: Forty eight male rabbits were subjected to 40 min MI followed by R for 3 h and were randomly received one of the following treatments: saline, GIK (glucose: 150 g/L, insulin: 60 U/L and KCl: 80 mmol/L), or… CONTINUE READING