Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects.

@article{Marzo2009RoleOI,
  title={Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects.},
  author={Vincenzo Di Marzo and An Verrijken and Antti Hakkarainen and Stefania Petrosino and Ilse Mertens and Nina Lundbom and Fabiana Piscitelli and Jukka Westerbacka and Aino Soro-Paavonen and Isabel Matias and Luc Van Gaal and Marja-Riitta Taskinen},
  journal={European journal of endocrinology},
  year={2009},
  volume={161 5},
  pages={715-22}
}
OBJECTIVE Endocannabinoids (ECs) control metabolism via cannabinoid receptors type 1 (CB1). Their plasma levels are elevated in overweight type 2 diabetes (T2D) and in obese patients, and decrease postprandially in normoweight individuals. We investigated in two different cohorts of nonobese or obese volunteers whether oral glucose in glucose tolerance tests (OGTT) or acute insulin infusion during euglycemic hyperinsulinemic clamp affect plasma EC levels. DESIGN AND METHODS OGTT was performed… CONTINUE READING

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Peripheral endocannabinoid dysregulation in two experimental models of obesity: potential relationships with intestinal motility and food deprivation/refeeding-induced energy processing

AA Izzo, F Piscitelli, +5 authors V. Di Marzo
British Journal of Pharmacology • 2009

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