Role of insulin and testosterone in prostatic growth: who is doing what?

@article{Vikram2011RoleOI,
  title={Role of insulin and testosterone in prostatic growth: who is doing what?},
  author={A. V. Vikram and Gopabandhu Jena},
  journal={Medical hypotheses},
  year={2011},
  volume={76 4},
  pages={474-8}
}
Previous studies have demonstrated increased incidence of benign prostatic hyperplasia in insulin-resistant individuals. In addition to androgens, prostatic growth is sensitive to the peptide growth factors including insulin. Experimental studies employing intervention of selective β-cell toxin streptozotocin and castration suggest that depletion of either insulin or testosterone results in the severe prostatic atrophy (>80%). Exogenous testosterone and diet-induced experimental… CONTINUE READING
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in insulin resistant rats : linking hyperinsulinemia with benign prostate hyperplasia

  • W Fan, T Yanase, H Morinaga
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