Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis.

@article{Jahoor1989RoleOI,
  title={Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis.},
  author={Farook Jahoor and Robert E. Shangraw and Hideyuki Miyoshi and H Wallfish and David N . Herndon and Robert R. Wolfe},
  journal={The American journal of physiology},
  year={1989},
  volume={257 3 Pt 1},
  pages={E323-31}
}
We have investigated the responsiveness of protein kinetics to insulin and the role of glucose oxidation rate as a mediator of the protein catabolic response to burn injury and sepsis by assessing the response of leucine and urea kinetics to a 5-h hyperinsulinemic euglycemic clamp with and without the simultaneous administration of dichloroacetate (DCA) (to further increase glucose oxidation via stimulation of pyruvate dehydrogenase activity) in eight severely burned and eight septic patients… CONTINUE READING