Role of insulin and adenosine in the human placenta microvascular and macrovascular endothelial cell dysfunction in gestational diabetes mellitus.

@article{GuzmnGutierrez2014RoleOI,
  title={Role of insulin and adenosine in the human placenta microvascular and macrovascular endothelial cell dysfunction in gestational diabetes mellitus.},
  author={Enrique Guzm{\'a}n-Gutierrez and Pablo Arroyo and Roc{\'i}o Salsoso and B{\'a}rbara Fuenzalida and T Estefan{\'i}a Saez and Andrea Leiva and F. Mart{\'i}nez Pardo and Luis Sobrevia},
  journal={Microcirculation},
  year={2014},
  volume={21 1},
  pages={
          26-37
        }
}
Microvascular and macrovascular endothelial function maintains vascular reactivity. Several diseases alter endothelial function, including hypertension, obesity, and diabetes mellitus. In addition, micro- and macrovascular endothelial dysfunction is documented in GDM with serious consequences for the growing fetus. Increased l-arginine uptake via hCAT-1 and NO synthesis by eNOS is associated with GDM. These alterations are paralleled by activation of purinergic receptors and increased umbilical… CONTINUE READING
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