Role of insulin‐like growth factor binding protein‐3 in breast cancer cell growth

@article{Schedlich2002RoleOI,
  title={Role of insulin‐like growth factor binding protein‐3 in breast cancer cell growth},
  author={Lynette J. Schedlich and Lloyd D. Graham},
  journal={Microscopy Research and Technique},
  year={2002},
  volume={59}
}
The mitogenic effects of insulin‐like growth factors (IGFs) are regulated by a family of insulin‐like growth factor binding proteins (IGFBPs). One member of this family, IGFBP‐3, mediates the growth‐inhibitory and apoptosis‐inducing effects of a number of growth factors and hormones such as transforming growth factor‐β, retinoic acid, and 1,25‐dihydroxyvitamin D3. IGFBP‐3 may act in an IGF‐dependent manner by attenuating the interaction of pericellular IGFs with the type‐I IGF receptor. It may… 
Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts.
TLDR
It is suggested that IGFBP-5 may attenuate the 1,25(OH)2D3-induced expression of bone differentiation markers while having a modest effect on the 1-25( OH)2 D3-mediated inhibition of cell cycle progression in bone cells.
Cellular Internalization of Insulin-like Growth Factor Binding Protein-3
TLDR
Together, these data indicate that the actions of IGFBP-3 are mediated by internalization via distinct endocytic pathways.
The insulin-like growth factor system in advanced breast cancer.
  • S. Helle
  • Medicine, Biology
    Best practice & research. Clinical endocrinology & metabolism
  • 2004
Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems.
TLDR
The role and mechanisms of action of the GH and IGF systems in skin and maintenance of epidermal integrity in both health and disease are focused on.
Immunohistochemical expression of insulin-like growth factor binding protein-3 in invasive breast cancers and ductal carcinoma in situ: implications for clinicopathology and patient outcome
TLDR
Increased breast epithelial IGFBP-3 expression is a feature of tumorigenesis with cytoplasmic immunoreactivity in the absence of significant nuclear localisation in IDCs and DCIS, suggesting that IGF BP-3 is a potential mitogen.
Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation.
TLDR
Phosphorylation of IGFBP-3 by nuclear DNA-PK provides a means for releasing bound IGF-I and creating a phosphoform of IGF BP-3 with increased affinity for nuclear components, which is suggested to be an important mechanism for controlling nuclear protein import.
Inhibition of Type I Insulin-Like Growth Factor Receptor Signaling Attenuates the Development of Breast Cancer Brain Metastasis
TLDR
It is demonstrated that IGF-IR is constitutively autophosphorylated in brain-seeking breast cancer sublines and its ablation delays the onset of brain metastases in the model system.
Serum insulin-like growth factors, insulin-like growth factor binding proteins, and breast cancer risk in postmenopausal women.
  • H. Grønbaek, A. Flyvbjerg, K. Overvad
  • Medicine, Biology
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2004
TLDR
Serum IGFBP-3 and IGF-II levels were positively associated with ER-positive breast cancer risk and may suggest an important relationship among IGFs, IGFBPs, the ER system, and breast cancer development in postmenopausal women.
ROLE OF ENDOGENOUS IGFBP-3 IN MAMMARY EPITHELIAL CELL APOPTOSIS
TLDR
It is shown that IGFBP-3 plays a role in stress-induced apoptosis that may require nuclear localization in non-transformed MEC, and treatment with IGF-I had no effect on ANs-induced nuclear localization, but did block ANS-induced suicides.
IGF-I differentially regulates IGF-binding protein expression in primary mammary fibroblasts and epithelial cells.
TLDR
The analysis of cell-type-specific regulation of the IGF system in both primary mammary epithelial cells and stromal cells will assist in the characterization of the mechanisms behind the role of theIGFBPs in normal mammary physiology and ultimately breast cancer.
...
...

References

SHOWING 1-10 OF 115 REFERENCES
Differential IGF‐independent effects of insulin‐like growth factor binding proteins (1–6) on apoptosis of breast epithelial cells
TLDR
Evidence is provided to suggest that individual IGFBPs have specific IGF‐independent effects and act differentially on apoptotic signalling pathways, as compared to IGFBP‐3, which significantly accentuated C2‐induced apoptosis.
Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism*
TLDR
It is suggested that IGFBP-3 induces apoptosis through a novel pathway independent of either p53 or the IGF·IGF receptor-mediated cell survival pathway and that IGF BP-3 mediates TGF-β1 induced apoptosis in PC-3 cells.
Expression of insulin‐like growth factor binding proteins in human breast cancer correlates with estrogen receptor status
TLDR
Differential IGFBP expression in ER positive and negative tumors suggests an important role for this protein in breast cancer biology, and the presence of IGFBPs in Breast cancer tissues is confirmed.
Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells.
TLDR
The results suggest that IGFBP-3 enhances apoptosis by reducing bioavailability of ligands for the IGF-I receptor and suggest that modulation of IGF BP-3 expression by ICI contributes to apoptosis induced by this compound, suggesting that IGFBPs are regulators of apoptosis.
Insulin‐like growth factor‐binding protein enhancement of insulin‐like growth factor‐i (IGF‐I)–mediated DNA synthesis and IGF‐I binding in a human breast carcinoma cell line
  • Jian‐Chyi Chen, Z. Shao, J. Fontana
  • Biology, Medicine
    Journal of cellular physiology
  • 1994
TLDR
In conclusion, IGFBP‐3 secreted by MCF‐7 cells can enhance IGF‐l stimulation of DNA synthesis, increase IGF‐ l binding to these cells, and prevent IGF–l–induced desensitization of its own receptor, suggesting that IGFBP•3 plays a significant role in IGF-l–mediated breast carcinoma proliferation.
Insulin-like Growth Factor Binding Protein 3 Mediates Retinoic Acid- and Transforming Growth Factor β2-induced Growth Inhibition in Human Breast Cancer Cells
TLDR
Evidence is provided that IGFBP-3 is an important mediator of RA-and TGF-β2-induced cell growth inhibition in human breast cancer cells, and an antisense IGF BP-3 oligodeoxynucleotide (ODN) which specifically inhibits IGFBP -3 expression is used to test this hypothesis.
Insulin‐like growth‐factor‐binding protein 3 is decreased in early‐stage operable pre‐menopausal breast cancer
TLDR
Increased levels of available IGF‐1 in the circulation of pre‐menopausal women may contribute to the development of breast cancer.
Differential Regulation of Insulin-Like Growth Factor-Binding Protein-3 Protease Activity in MCF-7 Breast Cancer Cells by Estrogen and Transforming Growth Factor-β1.
TLDR
It is demonstrated that estrogens and TGFβ1, factors that are stimulatory and inhibitory, respectively, for MCF-7 cell gr...
The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.
TLDR
It is concluded that the cellular production of IGFBPs serves as a negative regulator of cell proliferation which involves a cellular signaling pathway separate from the IGF-IGF-R system.
Retinoid modulation of insulin-like growth factor-binding proteins and inhibition of breast carcinoma proliferation.
TLDR
The hypothesis that RA may inhibit the growth of certain breast carcinoma cells by increasing the secretion of certain IGF-BPs, which could directly modulate the growth effect of IGFs is supported.
...
...