Role of insulin‐like growth factor binding protein‐3 in breast cancer cell growth
@article{Schedlich2002RoleOI, title={Role of insulin‐like growth factor binding protein‐3 in breast cancer cell growth}, author={Lynette J. Schedlich and Lloyd D. Graham}, journal={Microscopy Research and Technique}, year={2002}, volume={59} }
The mitogenic effects of insulin‐like growth factors (IGFs) are regulated by a family of insulin‐like growth factor binding proteins (IGFBPs). One member of this family, IGFBP‐3, mediates the growth‐inhibitory and apoptosis‐inducing effects of a number of growth factors and hormones such as transforming growth factor‐β, retinoic acid, and 1,25‐dihydroxyvitamin D3. IGFBP‐3 may act in an IGF‐dependent manner by attenuating the interaction of pericellular IGFs with the type‐I IGF receptor. It may…
46 Citations
Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts.
- Biology, MedicineMolecular endocrinology
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It is suggested that IGFBP-5 may attenuate the 1,25(OH)2D3-induced expression of bone differentiation markers while having a modest effect on the 1-25( OH)2 D3-mediated inhibition of cell cycle progression in bone cells.
Cellular Internalization of Insulin-like Growth Factor Binding Protein-3
- Biology, MedicineJournal of Biological Chemistry
- 2004
Together, these data indicate that the actions of IGFBP-3 are mediated by internalization via distinct endocytic pathways.
The insulin-like growth factor system in advanced breast cancer.
- Medicine, BiologyBest practice & research. Clinical endocrinology & metabolism
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Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems.
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The role and mechanisms of action of the GH and IGF systems in skin and maintenance of epidermal integrity in both health and disease are focused on.
Immunohistochemical expression of insulin-like growth factor binding protein-3 in invasive breast cancers and ductal carcinoma in situ: implications for clinicopathology and patient outcome
- Biology, MedicineBreast Cancer Research
- 2004
Increased breast epithelial IGFBP-3 expression is a feature of tumorigenesis with cytoplasmic immunoreactivity in the absence of significant nuclear localisation in IDCs and DCIS, suggesting that IGF BP-3 is a potential mitogen.
Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation.
- Biology, MedicineEndocrinology
- 2003
Phosphorylation of IGFBP-3 by nuclear DNA-PK provides a means for releasing bound IGF-I and creating a phosphoform of IGF BP-3 with increased affinity for nuclear components, which is suggested to be an important mechanism for controlling nuclear protein import.
Inhibition of Type I Insulin-Like Growth Factor Receptor Signaling Attenuates the Development of Breast Cancer Brain Metastasis
- Biology, MedicinePloS one
- 2013
It is demonstrated that IGF-IR is constitutively autophosphorylated in brain-seeking breast cancer sublines and its ablation delays the onset of brain metastases in the model system.
Serum insulin-like growth factors, insulin-like growth factor binding proteins, and breast cancer risk in postmenopausal women.
- Medicine, BiologyCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- 2004
Serum IGFBP-3 and IGF-II levels were positively associated with ER-positive breast cancer risk and may suggest an important relationship among IGFs, IGFBPs, the ER system, and breast cancer development in postmenopausal women.
ROLE OF ENDOGENOUS IGFBP-3 IN MAMMARY EPITHELIAL CELL APOPTOSIS
- Biology
- 2014
It is shown that IGFBP-3 plays a role in stress-induced apoptosis that may require nuclear localization in non-transformed MEC, and treatment with IGF-I had no effect on ANs-induced nuclear localization, but did block ANS-induced suicides.
IGF-I differentially regulates IGF-binding protein expression in primary mammary fibroblasts and epithelial cells.
- Biology, MedicineThe Journal of endocrinology
- 2005
The analysis of cell-type-specific regulation of the IGF system in both primary mammary epithelial cells and stromal cells will assist in the characterization of the mechanisms behind the role of theIGFBPs in normal mammary physiology and ultimately breast cancer.
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