Role of insulin‐like growth factor binding protein‐3 in breast cancer cell growth

@article{Schedlich2002RoleOI,
  title={Role of insulin‐like growth factor binding protein‐3 in breast cancer cell growth},
  author={Lynette J. Schedlich and Lloyd D. Graham},
  journal={Microscopy Research and Technique},
  year={2002},
  volume={59}
}
The mitogenic effects of insulin‐like growth factors (IGFs) are regulated by a family of insulin‐like growth factor binding proteins (IGFBPs). One member of this family, IGFBP‐3, mediates the growth‐inhibitory and apoptosis‐inducing effects of a number of growth factors and hormones such as transforming growth factor‐β, retinoic acid, and 1,25‐dihydroxyvitamin D3. IGFBP‐3 may act in an IGF‐dependent manner by attenuating the interaction of pericellular IGFs with the type‐I IGF receptor. It may… 
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