Role of innervation in the control of bone remodeling.

  • Chantal Chenu
  • Published 2004 in
    Journal of musculoskeletal & neuronal…


During the last fifteen years, an increasing number of studies have examined the origin, the ontogeny, and the distribution of nerve fibers in bone. They have also investigated the nature of neuromediators conveyed by these skeletal nerve fibers. Experimental models of sensory and sympathetic denervation and clinical studies have shown that these two neuronal systems are involved in bone development, growth and remodeling. More recently, some new concepts regarding the role of nerve fibers in bone physiology have emerged with the demonstration of a leptin-dependent central control of bone formation via the sympathetic system. This new neural regulating pathway of bone cell functions could have enormous implications for human skeletal biology and treatment of bone pathologies.

Extracted Key Phrases

Citations per Year

134 Citations

Semantic Scholar estimates that this publication has 134 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Chenu2004RoleOI, title={Role of innervation in the control of bone remodeling.}, author={Chantal Chenu}, journal={Journal of musculoskeletal & neuronal interactions}, year={2004}, volume={4 2}, pages={132-4} }