Role of innate and adaptive immune mechanisms in cardiac injury and repair

@article{Epelman2015RoleOI,
  title={Role of innate and adaptive immune mechanisms in cardiac injury and repair},
  author={S. Epelman and P. Liu and D. Mann},
  journal={Nature Reviews Immunology},
  year={2015},
  volume={15},
  pages={117-129}
}
Despite the advances that have been made in developing new therapeutics, cardiovascular disease remains the leading cause of worldwide mortality. Therefore, understanding the mechanisms underlying cardiovascular tissue injury and repair is of prime importance. Following cardiac tissue injury, the immune system has an important and complex role in driving both the acute inflammatory response and the regenerative response. This Review summarizes the role of the immune system in cardiovascular… Expand
295 Citations

Figures and Topics from this paper

Role of inflammatory cells in fibroblast activation.
  • 48
Role of the immune system in cardiac tissue damage and repair following myocardial infarction
  • 17
Cardioimmunology: the immune system in cardiac homeostasis and disease
  • 125
  • PDF
Role of Inflammatory Cell Subtypes in Heart Failure
  • 13
  • PDF
Cardiac Immunology: A New Era for Immune Cells in the Heart.
Immune Modulation of Cardiac Arrhythmias.
  • B. London
  • Biology, Medicine
  • Circulation research
  • 2017
  • 1
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 172 REFERENCES
Innate immunity in the adult mammalian heart: for whom the cell tolls.
  • 41
The interplay between macrophages and angiogenesis in development, tissue injury and regeneration.
  • 177
  • PDF
Complement activation in heart diseases. Role of oxidants.
  • 67
Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart
  • 352
  • PDF
The mechanistic basis of infarct healing.
  • 254
Macrophages are required for neonatal heart regeneration.
  • 444
  • PDF
...
1
2
3
4
5
...