Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.

@article{Mishra2013RoleOI,
  title={Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.},
  author={Avshesh Mishra and Anshika Srivastava and Tulika Mittal and Naveen Garg and Balraj Mittal},
  journal={Cytokine},
  year={2013},
  volume={61 3},
  pages={
          856-61
        }
}

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References

SHOWING 1-10 OF 45 REFERENCES
Impact of Renin-Angiotensin-Aldosterone System Gene Polymorphisms on Left Ventricular Dysfunction in Coronary Artery Disease Patients
TLDR
AT1 A1166C plays important role in conferring susceptibility of LVD through association of single nucleotide polymorphisms in angiotensin I converting enzyme and aldosterone synthase with LVD.
Nuclear Factor (NF) κB polymorphism is associated with heart function in patients with heart failure
TLDR
The data suggest that a diminished activation of NFKB1, previously associated with the ATTG1/ATTG1 genotype, may act modulating on the onset of disease and, once the individual has HF, the genotype may modulate disease severity by increasing cardiac remodeling and function deterioration.
Association of 25 bp Deletion in MYBPC3 Gene with Left Ventricle Dysfunction in Coronary Artery Disease Patients
TLDR
The frequency of MYBPC3 DW genotype and D allele was associated with compromised LVEF implying that genetic variants of myosin binding protein C encoding mutant structural sarcomere protein could increase susceptibility to left ventricular dysfunction.
Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients.
Inflammatory cytokine gene variants in coronary artery disease patients in Greece
TLDR
Evidence is provided that the IL-6-174G/C polymorphism may be involved in the pathogenesis of coronary artery disease, contributing to genetic susceptibility for myocardial infarction.
Associations between angiotensinogen gene variants and left ventricular mass and function in the HyperGEN study.
TLDR
Variation in the angiotensinogen gene was modestly associated with LV mass independently of covariates in patients with hypertensive conditions, probably because of the influence of other risk factors or antihypertensive medication use or both.
The –308 G/A Tumor Necrosis Factor-α Gene Dimorphism: A Risk Factor for Unstable Angina
TLDR
The crucial role of TNF-α is suggested in the mechanisms responsible for unstable angina in accordance with the concept of vulnerable plaque as well as mechanisms controlling myocardial infarction appear more complex and heterogeneous.
The -308 G/A tumor necrosis factor-alpha gene dimorphism: a risk factor for unstable angina.
TLDR
The results suggest the crucial role of TNF-alpha in the mechanisms responsible for unstable angina in accordance with the concept of vulnerable plaque, and mechanisms controlling myocardial infarction appear more complex and heterogeneous.
The interleukin-6 –174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study
TLDR
The interleukin-6 –174-G/C promoter polymorphism appears to influence levels of inflammatory markers, which have been shown to be associated with arterial stiffness, and this polymorphism is associated with increased arterIAL stiffness and pulse pressure.
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