Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy.

  title={Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy.},
  author={Yam Nath Paudel and Mohd. Farooq Shaikh and Sadia Shah and Yatinesh Kumari and Iekhsan Othman},
  journal={European journal of pharmacology},

Epilepsy and Comorbidities: Towards unraveling the common underlying mechanisms

The precise understanding of the mechanistic pathway underlying these epilepsy-associated comorbid conditions could be instrumental in developing therapeutic interventions that might modify seizure burden and accompanying comorbrid conditions.

The role of interleukin-17 in epilepsy

Inflammation: Cause or Consequence of Epilepsy?

  • V. LeeM. Shaikh
  • Psychology, Medicine
    Epilepsy - Advances in Diagnosis and Therapy
  • 2019
The involvement of inflammatory mediators in the development and progression of seizures and epileptogenesis is discussed, supported by clinical shreds of evidence, and the role of inflammation in the generation of seizures is discussed.

Role of inflammation in childhood epilepsy and ADHD comorbidity

Children with ADHD have been found to have a significantly lower age of onset, longer duration of epilepsy, and a higher serum level of IL-6 and TNF-α than those without ADHD.

Impact of Stress on Epilepsy: Focus on Neuroinflammation—A Mini Review

Mechanistic insight into the impact of stress on epilepsy may create a window of opportunity for future interventions targeting neuroinflammation-related disorders.

From the Molecular Mechanism to Pre-clinical Results: Anti-epileptic Effects of Fingolimod

Emerging experimental findings suggest that Fingolimod treatment exerts disease-modifying anti-epileptic effects based on its anti-neuroinflammatory properties, potent neuroprotection, anti-gliotic effects, myelin protection, reduction of mTOR signaling pathway and activation of microglia and astrocytes.

Animal Models of Metabolic Epilepsy and Epilepsy Associated Metabolic Dysfunction: A Systematic Review

The present systematic review summarizes the current state of available animal models of metabolic dysfunction associated with epileptic disorders and suggests the pressing need of developing precise robust animal models and evaluation methods for investigating ME.



Neurobehavioral comorbidities of epilepsy: Role of inflammation

It appears likely that priming of the brain due to early inflammation could provide a means by which subsequent inflammatory processes associated with epilepsy, ASD, and depression may lead to comorbidity.

The role of inflammation in epilepsy

This work focuses on the rapidly growing body of evidence that supports the involvement of inflammatory mediators—released by brain cells and peripheral immune cells—in both the origin of individual seizures and the epileptogenic process.

The role of cytokines in the pathophysiology of epilepsy

Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

An evidence-based review of the literatures indicated that inflammation is a part of epileptogenesis, and further studies are necessary for assessing agents that will be effective in clinical use for therapeutic treatment of epilepsy.

Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?

  • A. Vezzani
  • Medicine, Biology
    Expert opinion on drug safety
  • 2015
Clinical translation of anti-inflammatory intervention may take advantage of drugs already used in clinical practice for peripheral or other CNS disorders with a pathogenic neuroinflammatory component, to represent disease-modifying treatments.