Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene.

@article{Fontaine2001RoleOI,
  title={Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene.},
  author={Sylvianne Fontaine and Patricia B. Hoyer and James R. Halpert and I. Glenn Sipes},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2001},
  volume={29 9},
  pages={1236-42}
}
4-Vinyl-1-cyclohexene (VCH) is ovotoxic in B6C3F(1) mice but not in Fischer-344 rats, which can be partially attributed to greater formation of toxic epoxides from VCH in mice compared with rats. Since repeated exposure to VCH is necessary to cause ovotoxicity in mice, it is important to determine whether repeated exposure results in induction of cytochrome P450 (CYP) enzymes involved in its bioactivation. Hepatic microsomes prepared from mice or rats treated repeatedly with VCH demonstrated… CONTINUE READING