Role of inducible nitric oxide synthase expressed by alveolar macrophages in High Mobility Group Box 1- induced acute lung injury

@article{Ren2006RoleOI,
  title={Role of inducible nitric oxide synthase expressed by alveolar macrophages in High Mobility Group Box 1- induced acute lung injury},
  author={Da-bin Ren and R. Sun and S. Wang},
  journal={Inflammation Research},
  year={2006},
  volume={55},
  pages={207-215}
}
The role of inducible nitric oxide synthase (iNOS) expressed by alveolar macrophages in acute lung injury induced by high mobility group box 1 (HMGB1) was explored. Primary rat alveolar macrophages (PRAMs) were stimulated with HMGB1 to analyze iNOS expression. Alveolar macrophages and iNOS were inhibited by gadolinium chloride and 1400W in rats challenged by HMGB1 intratracheally. Western Blot was applied to assay iNOS expression in PRAMs. Indices for acute lung injury in rats were measured… CONTINUE READING