Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immuno-regulation: tryptophan depletion versus production of toxic kynurenines.

@article{MacKenzie2007RoleOI,
  title={Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immuno-regulation: tryptophan depletion versus production of toxic kynurenines.},
  author={Colin R MacKenzie and Kathrin Heseler and Anika M{\"u}ller and Walter D{\"a}ubener},
  journal={Current drug metabolism},
  year={2007},
  volume={8 3},
  pages={237-44}
}
Tryptophan metabolism occurs via the protohemoprotein enzymes tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), the latter action of which has a number of effects in the body including both antimicrobial defence and immune regulation. Whilst the antimicrobial action of IDO is largely due to depletion of the essential amino acid tryptophan, the immune regulatory function of IDO is still unclear and controversial. The list of pathogens that are "sensitive" to IDO-mediated… CONTINUE READING

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