Role of individual ionic current systems in the SA node hypothesized by a model study.

@article{Sarai2003RoleOI,
  title={Role of individual ionic current systems in the SA node hypothesized by a model study.},
  author={Nobuaki Sarai and S. Matsuoka and Shinobu Kuratomi and Kyoichi Ono and Akinori Noma},
  journal={The Japanese journal of physiology},
  year={2003},
  volume={53 2},
  pages={125-34}
}
This paper discusses the development of a cardiac sinoatrial (SA) node pacemaker model. The model successfully reconstructs the experimental action potentials at various concentrations of external Ca2+ and K+. Increasing the amplitude of L-type Ca2+ current (I(CaL)) prolongs the duration of the action potential and thereby slightly decreases the spontaneous rate. On the other hand, a negative voltage shift of I(CaL) gating by a few mV markedly increases the spontaneous rate. When the amplitude… CONTINUE READING