Role of increased DNA replication in the carcinogenic risk of nonmutagenic chemical carcinogens.

@article{Cunningham1996RoleOI,
  title={Role of increased DNA replication in the carcinogenic risk of nonmutagenic chemical carcinogens.},
  author={Michael L. Cunningham},
  journal={Mutation research},
  year={1996},
  volume={365 1-3},
  pages={
          59-69
        }
}
DNA replication is not an error-free process; therefore induction of cell proliferation with the requisite increase in DNA replication may be an important mechanism by which carcinogenesis can be induced by chemicals. Data presented in this overview indicate a positive association between increased cell proliferation and carcinogenesis, and illustrate the value of performing mechanistic studies such as cell proliferation assays in conjunction with short-term tests to further investigate the… CONTINUE READING

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