Role of in silico genotoxicity tools in the regulatory assessment of pharmaceutical impurities

@article{Fioravanzo2012RoleOI,
  title={Role of in silico genotoxicity tools in the regulatory assessment of pharmaceutical impurities},
  author={Elena Fioravanzo and Arianna Bassan and Manuela Pavan and Aleksandra Mostrag-Szlichtyng and Andrew Paul Worth},
  journal={SAR and QSAR in Environmental Research},
  year={2012},
  volume={23},
  pages={257 - 277}
}
The toxicological assessment of genotoxic impurities is important in the regulatory framework for pharmaceuticals. In this context, the application of promising computational methods (e.g. Quantitative Structure–Activity Relationships (QSARs), Structure–Activity Relationships (SARs) and/or expert systems) for the evaluation of genotoxicity is needed, especially when very limited information on impurities is available. To gain an overview of how computational methods are used internationally in… 

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