Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy.

Abstract

BACKGROUND Tubulo-interstitial nephropathy (TIN) is a common cause of chronic kidney disease (CKD). Consumption of an adenine-containing diet causes the accumulation of 2,8-dihydroxyadenine in the renal tubules triggering intense chronic TIN and progressive CKD in rats. CKD in this model is associated with, and largely driven by, oxidative stress and… (More)
DOI: 10.1093/ndt/gft022

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Cite this paper

@article{Aminzadeh2013RoleOI, title={Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy.}, author={Mohammad Amin Aminzadeh and Susanne B. Nicholas and Keith C. Norris and Nosratola D. Vaziri}, journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association}, year={2013}, volume={28 8}, pages={2038-45} }