Role of immune cells in animal models for inherited peripheral neuropathies

  title={Role of immune cells in animal models for inherited peripheral neuropathies},
  author={Chi Wang Ip and Antje Kroner and Stefan Fischer and Martin Berghoff and Igor Kobsar and Mathias Maeurer and Rudolf Martini},
  journal={NeuroMolecular Medicine},
Mice expressing half of the normal dose of protein zero (P0+/− mice) or completely deficient gap-junction protein connexin 32−/− micemimic demyelinating forms of inherited neuropathies, such as Charcot-Marie-Tooth (CMT) neuropathies type 1B and CMT type 1X, respectively. In both models, an almost normal myelin formation is observed during the first months of life, followed by a slowly progressing demyelinating neuropathy. In both models, there is a substantial increase of CD8+ T-lymphocytes and… CONTINUE READING


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