Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.

@article{Lee2011RoleOI,
  title={Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.},
  author={Sang-Hyun Lee and Claus Peter Schneider and Ashlee N Higdon and Victor M. Darley-Usmar and Chang Y. Chung},
  journal={Traffic},
  year={2011},
  volume={12 7},
  pages={878-89}
}
Microglia are immune effector cells in the central nervous system (CNS) and their activation, migration and proliferation play crucial roles in brain injuries and diseases. We examined the role of intracellular Ca(2+) -independent phospholipase A(2) (iPLA(2)) in the regulation of microglia chemotaxis toward ADP. Inhibition of iPLA(2) by 4-bromoenol lactone (BEL) or iPLA(2) knockdown exerted a significant inhibition on phosphatidylinositol-3-kinase (PI3K) activation and chemotaxis. Further… CONTINUE READING