Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion

@article{Wang2007RoleOI,
  title={Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion},
  author={Xiao-Liang Wang and Hui-rong Liu and Lin Tao and Feng Liang and Li Yan and Rong-Rui Zhao and Bernard L. Lopez and Theodore A. Christopher and Xin-liang Ma},
  journal={Apoptosis},
  year={2007},
  volume={12},
  pages={1209-1217}
}
Polymorphonuclear leukocyte (PMN) accumulation/activation has been implicated as a primary mechanism underlying MI/R injury. Recent studies have demonstrated that PMNs express inducible nitric oxide synthase (iNOS) and produce toxic reactive nitrogen species (RNS). However, the role of iNOS-derived reactive nitrogen species and resultant nitrative stress in PMN-induced cardiomyocyte apoptosis after MI/R remains unclear. Male adult rats were subjected to 30 min of myocardial ischemia followed by… CONTINUE READING
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