Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice.

@article{Molinas2003RoleOH,
  title={Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice.},
  author={Carlos Roger Molinas and R. L. Campo and Osama Ali Elkelani and Maria Mercedes Binda and Peter Carmeliet and Philippe R. Koninckx},
  journal={Fertility and sterility},
  year={2003},
  volume={80 Suppl 2},
  pages={795-802}
}
OBJECTIVE To evaluate the role of hypoxia inducible factors (HIFs) 1alpha and 2alpha in adhesion formation after laparoscopic surgery. DESIGN Prospective, randomized study. SETTING Academic research center. ANIMAL(S) Forty Swiss/129SvJ wild-type mice and transgenic mice partially deficient for the genes encoding for HIF-1alpha (HIF-1alpha(+/-)) or HIF-2alpha (HIF-2alpha(+/-)). INTERVENTION(S) Adhesions were induced by standardized lesions during laparoscopy. To evaluate "basal adhesions… CONTINUE READING