Role of hypoxia in the hallmarks of human cancer.

  title={Role of hypoxia in the hallmarks of human cancer.},
  author={Kai Ruan and Gang Song and Gaoliang Ouyang},
  journal={Journal of cellular biochemistry},
  volume={107 6},
Hypoxia has been recognized as one of the fundamentally important features of solid tumors and plays a critical role in various cellular and physiologic events, including cell proliferation, survival, angiogenesis, immunosurveillance, metabolism, as well as tumor invasion and metastasis. These responses to hypoxia are at least partially orchestrated by activation of the hypoxia-inducible factors (HIFs). HIF-1 is a key regulator of the response of mammalian cells to oxygen deprivation and plays… CONTINUE READING


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