Role of hypoxemia and pulmonary mechanics in exercise limitation in interstitial lung disease.

@article{HarrisEze1996RoleOH,
  title={Role of hypoxemia and pulmonary mechanics in exercise limitation in interstitial lung disease.},
  author={A O Harris-Eze and G Sridhar and R M Clemens and Trevor Zintel and Charles G. Gallagher and Darcy D. Marciniuk},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={154 4 Pt 1},
  pages={994-1001}
}
We have previously shown that respiratory factors (arterial hypoxemia and/or pulmonary mechanics) contribute to limit maximal incremental exercise in interstitial lung disease (ILD). In this study, we tested the hypothesis that arterial hypoxemia, not pulmonary mechanics, primarily limits maximal exercise in subjects with ILD. Seven subjects with ILD underwent two incremental exercise tests in random order. Test 1: breathing room air (RA); Test 2: breathing 60% O2 with added external dead space… CONTINUE READING