Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.

@article{Nestler1997RoleOH,
  title={Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.},
  author={John Edwin Nestler},
  journal={Seminars in reproductive endocrinology},
  year={1997},
  volume={15 2},
  pages={111-22}
}
The polycystic ovary syndrome (PCOS) is a prevalent disorder affecting approximately 6% of women of reproductive age, and is characterized by anovulation and hyperandrogenism. It has also become apparent that a frequent feature of women with PCOS is insulin resistance accompanied by compensatory hyperinsulinemia, and increasing evidence suggests that hyperinsulinemia plays an important role in the pathogenesis of PCOS. This article will review (1) evidence indicating that insulin contributes to… CONTINUE READING