Role of hydroxyl radicals derived from granulocytes in lung injury induced by phorbol myristate acetate.

Abstract

Lung injury induced by phorbol myristate acetate (PMA) is closely associated with toxic oxidants released from activated granulocytes. But the major toxic oxidant causing lung damage is not really known. We have, therefore, conducted investigations using various oxygen radical scavengers. The intravenous administration of dimethylthiourea (DMTU), a potent… (More)

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