Role of hydroquinone-thiol conjugates in benzene-mediated toxicity.


Hydroquinone (HQ) is a metabolite of benzene, and in combination with phenol (PHE), reproduces benzene myelotoxicity. HQ readily oxidizes to 1,4-benzoquinone (1,4-BQ) followed by the reductive addition of glutathione (GSH). Subsequent cycles of oxidation and GSH addition give rise to a variety of mono-, and multi-GSH substituted conjugates. Following… (More)
DOI: 10.1016/j.cbi.2009.12.016


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@article{Lau2010RoleOH, title={Role of hydroquinone-thiol conjugates in benzene-mediated toxicity.}, author={Serrine S. Lau and Christopher L Kuhlman and Shawn B. Bratton and Terrence J. Monks}, journal={Chemico-biological interactions}, year={2010}, volume={184 1-2}, pages={212-7} }