Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor.

@article{Almlf1997RoleOH,
  title={Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor.},
  author={Tova Alml{\"o}f and J A Gustafsson and Anthony P. H. Wright},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 2},
  pages={934-45}
}
We have performed a mutagenesis analysis of the 58-amino-acid tau1-core peptide, which represents the core transactivation activity of the tau1 transactivation domain from the glucocorticoid receptor. Mutants with altered activity were identified by phenotypic screening in the yeast Saccharomyces cerevisiae. Most mutants with reduced activity had substitutions of hydrophobic amino acids. Most single-substitution mutants with reduced activity were localized near the N terminus of the tau1-core… CONTINUE READING

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