Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes.

@article{Bian2005RoleOH,
  title={Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes.},
  author={Jin-Song Bian and Qian Chen Yong and Ting-Ting Pan and Zhan-Ning Feng and Muhammed Yusuf Ali and Shou-kang Zhou and Philip Keith Moore},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={316 2},
  pages={
          670-8
        }
}
Endogenous H(2)S is synthesized mainly by cystathionine gamma-lyase in the heart. The present study investigated the role of H(2)S in cardioprotection induced by ischemic preconditioning. We have examined the effect of endogenous H(2)S and exogenous application of NaHS (H(2)S donor) on cardiac rhythm in the isolated rat heart subjected to low-flow ischemia insults as well as cell viability and function in isolated myocytes exposed to simulated ischemia solution. Preconditioning with NaHS (SP… CONTINUE READING

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