Role of hydrogen sulfide in severe burn injury-induced inflammation in mice.

@article{Zhang2010RoleOH,
  title={Role of hydrogen sulfide in severe burn injury-induced inflammation in mice.},
  author={Jing Zhang and Selena Wei Shan Sio and S. Moochhala and Madhav Bhatia},
  journal={Molecular medicine},
  year={2010},
  volume={16 9-10},
  pages={
          417-24
        }
}
Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in many types of mammalian cells from L-cysteine in the reactions catalyzed by cystathionine-β-synthase and cystathionine-γ-lyase (CSE). H(2)S has been demonstrated to play a proinflammatory role in various animal models of hindpaw edema, acute pancreatitis, lipopolysaccharide-induced endotoxemia and cecal ligation, and puncture-induced sepsis. Full-thickness burns that exceed 25% of the total body surface area (TBSA) produce a… CONTINUE READING