Role of hydrogen peroxide in the cytotoxicity of the xanthine/xanthine oxidase system.

@article{Link1988RoleOH,
  title={Role of hydrogen peroxide in the cytotoxicity of the xanthine/xanthine oxidase system.},
  author={Eva M. Link and Patrick A Riley},
  journal={The Biochemical journal},
  year={1988},
  volume={249 2},
  pages={391-9}
}
1. The survival of mammalian epithelial cells exposed in vitro to the xanthine/xanthine oxidase system in phosphate-buffered saline (PBS) or serum-containing medium (SCMEM) was investigated. 2. The cytotoxic effect observed depended on the composition of the medium in which the enzymic reaction was carried out; a surviving fraction of 5 x 10(-5) was found for cells exposed in PBS and 5.2 x 10(-1) for those in SCMEM. 3. The cytotoxic product(s) formed by the xanthine/xanthine oxidase system was… CONTINUE READING