Role of hydrogen peroxide in sperm capacitation and acrosome reaction.

  title={Role of hydrogen peroxide in sperm capacitation and acrosome reaction.},
  author={Joel Rivlin and Jane Mendel and Sara Rubinstein and Nir Etkovitz and H Breitbart},
  journal={Biology of reproduction},
  volume={70 2},
The generation of reactive oxygen species (ROS) has been implicated in the regulation of sperm capacitation and acrosome reaction; however, the mechanisms underlying this regulation remain unclear. To examine the cellular processes involved, we studied the effect of different concentrations of hydrogen peroxide (H(2)O(2)) on protein tyrosine phosphorylation under various conditions. Treatment of spermatozoa with H(2)O(2) in medium without heparin caused a time- and dose-dependent increase in… CONTINUE READING


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