Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin.

@article{Hemauer2010RoleOH,
  title={Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin.},
  author={Sarah J Hemauer and Svetlana L Patrikeeva and Tatiana N. Nanovskaya and Gary D. V. Hankins and Mahmoud S. Ahmed},
  journal={American journal of obstetrics and gynecology},
  year={2010},
  volume={202 4},
  pages={383.e1-7}
}
OBJECTIVE Substrates of placental efflux transporters could compete for a single transporter, which could result in an increase in the transfer of each substrate to the fetal circulation. Our aim was to determine the role of placental transporters in the biodisposition of oral hypoglycemic drugs that could be used as monotherapy or in combination therapy for gestational diabetes. STUDY DESIGN Inside-out brush border membrane vesicles from term placentas were used to determine the efflux of… CONTINUE READING