Role of human noncoding RNAs in the control of tumorigenesis.

@article{Li2009RoleOH,
  title={Role of human noncoding RNAs in the control of tumorigenesis.},
  author={Ling Li and Tingting Feng and Yingying Lian and Guangfeng Zhang and Alan Garen and Xu Song},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 31},
  pages={
          12956-61
        }
}
Related studies showed that the protein PSF represses proto-oncogene transcription, and VL30-1 RNA, a mouse noncoding retroelement RNA, binds and releases PSF from a proto-oncogene, activating transcription. Here we show that this mechanism regulates tumorigenesis in human cells, with human RNAs replacing VL30-1 RNA. A library of human RNA fragments was used to isolate, by affinity chromatography, 5 noncoding RNA fragments that bind to human PSF (hPSF), releasing hPSF from a proto-oncogene and… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 13 REFERENCES

Roles of PSF protein and VL30 RNA in reversible gene regulation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 16 EXCERPTS

Characterization of the GAGE genes that are expressed in various human cancers and in normal testis

O DeBacker
  • Cancer Res 59:3157–3165. Li et al. PNAS August
  • 1999
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

A Correction

X Song, Y Sun, Garen
  • Proc Natl Acad Sci USA
  • 2005
VIEW 2 EXCERPTS