Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core.

@article{Briones2010RoleOH,
  title={Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core.},
  author={Marisa S Briones and Charles W Dobard and Samson A. Chow},
  journal={Journal of virology},
  year={2010},
  volume={84 10},
  pages={5181-90}
}
After membrane fusion with a target cell, the core of human immunodeficiency virus type 1 (HIV-1) enters into the cytoplasm, where uncoating occurs. The cone-shaped core is composed of the viral capsid protein (CA), which disassembles during uncoating. The underlying factors and mechanisms governing uncoating are poorly understood. Several CA mutations can cause changes in core stability and a block at reverse transcription, demonstrating the requirement for optimal core stability during viral… CONTINUE READING
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