Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate.

@article{Kobayashi2000RoleOH,
  title={Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate.},
  author={Kaoru Kobayashi and Nobuhito Mimura and Hideki Fujii and Hironobu Minami and Yu F Sasaki and Noriaki Shimada and Kan Chiba},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 8},
  pages={3297-303}
}
Medroxyprogesterone acetate (MPA) is a drug commonly used in endocrine therapy for advanced or recurrent breast cancer and endometrial cancer. The drug is extensively metabolized in the intestinal mucosa and in the liver. Cytochrome P450s (CYPs) involved in the metabolism of MPA were identified by using human liver microsomes and recombinant human CYPs. In this study, the overall metabolism of MPA was determined as the disappearance of the parent drug from an incubation mixture. The… CONTINUE READING

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