Role of human T-cell leukemia virus type I Tax in expression of the human telomerase reverse transcriptase (hTERT) gene in human T-cells.

Abstract

The viral product Tax encoded by human T-cell leukemia virus type I (HTLV-I) is thought to play a central role in leukemogenesis. Clonal expansion of HTLV-I-infected cells requires the extension of cell division with telomere maintenance, which is regulated by the ribonucleoprotein enzyme telomerase. However, the roles of Tax in the expression of telomerase… (More)
DOI: 10.1111/j.1349-7006.2008.00798.x

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@article{Hara2008RoleOH, title={Role of human T-cell leukemia virus type I Tax in expression of the human telomerase reverse transcriptase (hTERT) gene in human T-cells.}, author={Toshifumi Hara and Yuuki Matsumura-Arioka and Kiyoshi Ohtani and Masataka Nakamura}, journal={Cancer science}, year={2008}, volume={99 6}, pages={1155-63} }