Role of human GKN1 on APP processing in gastric cancer.

Abstract

Gastrokine 1 (GKN1) is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1 belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. We previously demonstrated that a recombinant human GKN1 protein was able to interact with the amyloid precursor protein… (More)
DOI: 10.1016/j.biochi.2017.02.007

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