Role of homologous recombination in trabectedin-induced DNA damage.

@article{Tavecchio2008RoleOH,
  title={Role of homologous recombination in trabectedin-induced DNA damage.},
  author={Michele Tavecchio and Matteo Simone and E. Gadioli Erba and Irene Chiolo and Giordano Liberi and Marco Foiani and Maurizio D'Incalci and Giovanna Damia},
  journal={European journal of cancer},
  year={2008},
  volume={44 4},
  pages={609-18}
}
Trabectedin (ET-743, Yondelis) is a natural marine compound with antitumour activity currently undergoing phase II/III clinical trials. The mechanism of the drug's action is still to be defined, even though it has been clearly demonstrated the key role of Nucleotide Excision Repair (NER). To get further insights into the drug's mode of action, we studied… CONTINUE READING