Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions.

@article{Rosato2008RoleOH,
  title={Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions.},
  author={Roberto R. Rosato and Jorge A. Almenara and Sonia C. Maggio and Stefanie Coe and Peter W Atadja and Paul Dent and Steven Grant},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 10},
  pages={3285-97}
}
The role of reactive oxygen species (ROS) production on DNA damage and potentiation of fludarabine lethality by the histone deacetylase inhibitor (HDACI) LAQ-824 was investigated in human leukemia cells. Preexposure (24 h) of U937, HL-60, Jurkat, or K562 cells to LAQ-824 (40 nmol/L) followed by fludarabine (0.4 micromol/L) dramatically potentiated apoptosis (>or=75%). LAQ-824 triggered an early ROS peak (30 min-3 h), which declined by 6 h, following LAQ-824-induced manganese superoxide… CONTINUE READING
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