Role of histone deacetylase inhibitor in adenovirus-mediated p53 gene therapy in esophageal cancer.

Abstract

BACKGROUND Recently, the use of histone deacetylase inhibitors (HDACI) with gene therapy has been shown to improve the effect of this therapy. The effectiveness of one of the novel HDACIs, FK228, was examined in adenovirus-mediated p53 gene therapy of esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS The expression levels of coxsackie and… (More)

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Cite this paper

@article{Hoshino2008RoleOH, title={Role of histone deacetylase inhibitor in adenovirus-mediated p53 gene therapy in esophageal cancer.}, author={Isamu Hoshino and Hisahiro Matsubara and Yasunori Akutsu and Takanori Nishimori and Yasuo Yoneyama and Kentaro Murakami and Haruhito Sakata and Kazuyuki Matsushita and Aki Komatsu and Ryan Brooks and Takenori Ochiai}, journal={Anticancer research}, year={2008}, volume={28 2A}, pages={665-71} }