Role of histone H2A ubiquitination in Polycomb silencing

  title={Role of histone H2A ubiquitination in Polycomb silencing},
  author={Hengbin Wang and L. Wang and H. Erdjument-Bromage and M. Vidal and P. Tempst and R. S. Jones and Y. Zhang},
  • Hengbin Wang, L. Wang, +4 authors Y. Zhang
  • Published 2004
  • Biology, Medicine
  • Nature
  • Covalent modification of histones is important in regulating chromatin dynamics and transcription. One example of such modification is ubiquitination, which mainly occurs on histones H2A and H2B. Although recent studies have uncovered the enzymes involved in histone H2B ubiquitination and a ‘cross-talk’ between H2B ubiquitination and histone methylation, the responsible enzymes and the functions of H2A ubiquitination are unknown. Here we report the purification and functional characterization… CONTINUE READING
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