Role of histone H2A ubiquitination in Polycomb silencing

@article{Wang2004RoleOH,
  title={Role of histone H2A ubiquitination in Polycomb silencing},
  author={Hengbin Wang and Liangjun Wang and Hediye Erdjument-Bromage and Miguel Vidal and Paul Tempst and Richard S. Jones and Yi Zhang},
  journal={Nature},
  year={2004},
  volume={431},
  pages={873-878}
}
Covalent modification of histones is important in regulating chromatin dynamics and transcription. One example of such modification is ubiquitination, which mainly occurs on histones H2A and H2B. Although recent studies have uncovered the enzymes involved in histone H2B ubiquitination and a ‘cross-talk’ between H2B ubiquitination and histone methylation, the responsible enzymes and the functions of H2A ubiquitination are unknown. Here we report the purification and functional characterization… Expand
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