Role of histamine in rodent antinociception

@article{MalmbergAiello1994RoleOH,
  title={Role of histamine in rodent antinociception},
  author={P. Malmberg-Aiello and C. Lamberti and C. Ghelardini and A. Giotti and A. Bartolini},
  journal={British Journal of Pharmacology},
  year={1994},
  volume={111}
}
1 Effects of substances which are able to alter brain histamine levels on the nociceptive threshold were investigated in mice and rats by means of tests inducing three different kinds of noxious stimuli: mechanical (paw pressure), chemical (abdominal constriction) and thermal (hot plate). 2 A wide range of i.c.v. doses of histamine 2HCl was studied. Relatively high doses were dose‐dependently antinociceptive in all three tests: 5–100 μg per rat in the paw pressure test, 5–50 μg per mouse in the… Expand
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