Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat.

@article{Vianna2000RoleOH,
  title={Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat.},
  author={Monica Ryff Moreira Vianna and Mariana Mac{\'i}as Alonso and Hayd{\'e}e Viola and Jo{\~a}o Quevedo and Fernanda de Paris and M Furman and Miguelina Levi de Stein and Jorge H. Medina and Ivan Antonio Izquierdo},
  journal={Learning \& memory},
  year={2000},
  volume={7 5},
  pages={
          333-40
        }
}
Long-term habituation to a novel environment is one of the most elementary forms of nonassociative learning. Here we studied the effect of pre- or posttraining intrahippocampal administration of drugs acting on specific molecular targets on the retention of habituation to a 5-min exposure to an open field measured 24 h later. We also determined whether the exposure to a novel environment resulted in the activation of the same intracellular signaling cascades previously shown to be activated… Expand
Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning.
  • M. Vianna, L. Izquierdo, +5 authors I. Izquierdo
  • Medicine
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2001
TLDR
The present findings point to important biochemical differences in memory consolidation processes of the two tasks, which caused retrograde amnesia in rats implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus. Expand
Phosphorylation state of CREB in the rat hippocampus: A molecular switch between spatial novelty and spatial familiarity?
TLDR
The experiments revealed that the relevant variable to induce CREB deactivation was the prolonged exploration of the arena, and suggested that CREB phosphorylation state in the hippocampus switches in response to exposure to a novel or to a familiar spatial environment. Expand
Dopamine D1/D5 receptors in the dorsal hippocampus are required for the acquisition and expression of a single trial cocaine-associated memory
TLDR
It is suggested that dopaminergic inputs to the dorsal hippocampus are required for the acquisition and expression of one trial cocaine-associated memory while neural activity of this structure is needed for the late consolidation of these types of memories. Expand
Effects of intrahippocampal injection of GABAergic drugs on memory retention of passive avoidance learning in rats
TLDR
It is concluded that GABAA and GABAB receptor activation may be involved in the impairment of memory retention in rats and physostigmine improved memory retention. Expand
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TLDR
It is suggested that for the hippocampus to form associative spatial memories through LTP-like processes, it must first undergo learning of the context per se through exploration and the learning of familiarity, which requires LTD- like processes. Expand
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TLDR
It is suggested that NAcc-PKC-gamma plays a role during the early acquisition of spatial learning and retention of spatial memory consolidation within the nucleus accumbens using an antisense knockdown approach. Expand
The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear
TLDR
It is reported that extinction is triggered by two hippocampal signaling pathways underlying retrieval and two other mechanisms that become activated at the same time and are not necessary for retrieval, which are similar to those described for the acquisition and/or consolidation of the original contextual fear. Expand
GluN1 and GluN2A NMDA Receptor Subunits Increase in the Hippocampus during Memory Consolidation in the Rat
TLDR
The results showed that the NMDAR subunits increase follows a similar time course both in vitro and in vivo, and appears to be a general feature after novel “spatial/discrimination” memory acquisition. Expand
Dorsal hippocampus infusions of CNQX into the dentate gyrus disrupt expression of trace fear conditioning
TLDR
A role for the DG in the expression of trace tone fear conditioning is supported and targeted DH subregions CA1 and dentate gyrus (DG) are targeted for involvement in trace fear conditioning. Expand
Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty
TLDR
The tagging-and-capture mechanism through which novelty enhances fear extinction involves more molecular processes than hitherto thought: NMDA receptors, L-VDCCs, CaMKII, and synaptic protein turnover. Expand
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