Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis

@article{DarashYahana2004RoleOH,
  title={Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis},
  author={M. Darash-Yahana and E. Pikarsky and R. Abramovitch and E. Zeira and Boaz Pal and R. Karplus and K. Beider and Shani Avniel and Shafika Kasem and E. Galun and A. Peled},
  journal={The FASEB Journal},
  year={2004},
  volume={18}
}
Hormone refractory metastatic prostate cancer remains an incurable disease. We found that high expression levels of the chemokine receptor CXCR4 correlated with the presence of metastatic disease in prostate cancer patients. Positive staining for CXCL12, the ligand for CXCR4, was mainly present in the tumor‐associated blood vessels and basal cell hyperplasia. Subcutaneous xenografts of PC3 and 22Rv1 prostate tumors that overexpressed CXCR4 in NOD/SCID mice were two‐ to threefold larger in… Expand
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