Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.

@article{Tsuboi2013RoleOH,
  title={Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.},
  author={Koichiro Tsuboi and Jotaro Hirakawa and Emiko Seki and Yasuyuki Imai and Yu Yamaguchi and Minoru Fukuda and Hiroto Kawashima},
  journal={Journal of immunology},
  year={2013},
  volume={191 1},
  pages={448-55}
}
Lymphocyte homing to peripheral lymph nodes (PLNs) is mediated by multistep interactions between lymphocytes and high endothelial venules (HEVs). Heparan sulfate (HS) has been implicated in the presentation of chemokines on the surface of HEVs during this process. However, it remains unclear whether this cell surface presentation is a prerequisite for lymphocyte homing. In this study, we generated conditional knockout (cKO) mice lacking Ext1, which encodes a glycosyltransferase essential for HS… CONTINUE READING

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