Role of heteromer formation in GABAB receptor function.

  title={Role of heteromer formation in GABAB receptor function.},
  author={Rohini Kuner and Georg K{\"o}hr and Sylvia Gr{\"u}newald and Gisela Eisenhardt and Anders Bach and H C Kornau},
  volume={283 5398},
Recently, GBR1, a seven-transmembrane domain protein with high affinity for gamma-aminobutyric acid (GABA)B receptor antagonists, was identified. Here, a GBR1-related protein, GBR2, was shown to be coexpressed with GBR1 in many brain regions and to interact with it through a short domain in the carboxyl-terminal cytoplasmic tail. Heterologously expressed GBR2 mediated inhibition of adenylyl cyclase; however, inwardly rectifying potassium channels were activated by GABAB receptor agonists only… CONTINUE READING
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