Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes.

@article{Rahimi1994RoleOH,
  title={Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes.},
  author={Nader Rahimi and Ronald B. Saulnier and Tetsuya Nakamura and Misoon Park and Bruce W. Elliott},
  journal={DNA and cell biology},
  year={1994},
  volume={13 12},
  pages={1189-97}
}
Stromal cells can dramatically affect the growth and metastatic capability of breast carcinoma cells. Growth factors, considered to be important mediators of this process, act as either mitogenic or mito-inhibitory regulators. We have developed an in vitro coculture system to examine the influence of adipocytes, a dominant mammary stromal cell type, on the growth of a murine mammary carcinoma, SP1. Previously, we have reported that conditioned medium (CM) from 3T3-L1 adipocytes can promote in… CONTINUE READING